Hruska R E, Pitman K T
Eur J Pharmacol. 1982 Nov 19;85(2):201-5. doi: 10.1016/0014-2999(82)90466-6.
The ability of haloperidol (HAL) at doses of 1, 2 and 4 mg/kg to increase the density of the striatal dopamine (DA) receptors was measured in normal and hypophysectomized (Hypox) male rats. In intact rats HAL significantly increased the receptor density at all three doses. In Hypox rats HAL produced significantly less of an increase, with only the 4 mg/kg dose producing a statistically significant increase. Therefore, Hypox appears to reduce the ability of HAL to increase striatal DA receptor density.
在正常和垂体切除的雄性大鼠中，测定了剂量为1、2和4mg/kg的氟哌啶醇（HAL）增加纹状体多巴胺（DA）受体密度的能力。在完整大鼠中，所有三个剂量的HAL均显著增加受体密度。在垂体切除的大鼠中，HAL产生的增加显著较少，只有4mg/kg剂量产生统计学上显著的增加。因此，垂体切除似乎降低了HAL增加纹状体DA受体密度的能力。
