Gordon J H, Diamond B I
J Neurochem. 1984 Feb;42(2):523-8. doi: 10.1111/j.1471-4159.1984.tb02709.x.
It has been reported that hypophysectomy (HYPOX) would antagonize the development of a neuroleptic-induced dopamine receptor hypersensitivity, and suggested that the neuroleptic-induced dopamine receptor hypersensitivity may be mediated by the neuroleptic-induced hyperprolactinemia. Conversely, we and others have reported on the ability of HYPOX animals to develop a neuroleptic-induced dopamine receptor hypersensitivity. The present study was undertaken to define the possible role(s) of prolactin in the modulation of striatal dopamine receptor sensitivity. The data from these studies indicate: that HYPOX alone will result in the development of a striatal dopamine receptor hypersensitivity; that the HYPOX-induced dopamine receptor hypersensitivity could be increased by the chronic administration and withdrawal of haloperidol; that administration of prolactin to HYPOX rats would partially antagonize the development of the neuroleptic-induced dopamine receptor hypersensitivity; and that the administration of prolactin alone had minimal effects on the apomorphine-induced behavior or neurochemistry of the HYPOX animals. These results suggest that the neuroleptics do not require the presence of a pituitary secretion (specifically, prolactin) to induce a striatal dopamine receptor hypersensitivity; however, they do indicate that a pituitary secretion, perhaps prolactin, may have the ability to modulate striatal dopamine sensitivity.
据报道，垂体切除术（HYPOX）可对抗抗精神病药物诱导的多巴胺受体超敏反应的发展，并提示抗精神病药物诱导的多巴胺受体超敏反应可能由抗精神病药物诱导的高催乳素血症介导。相反，我们和其他人报道了垂体切除动物发展抗精神病药物诱导的多巴胺受体超敏反应的能力。本研究旨在确定催乳素在调节纹状体多巴胺受体敏感性中的可能作用。这些研究的数据表明：单独的垂体切除术会导致纹状体多巴胺受体超敏反应的发展；垂体切除诱导的多巴胺受体超敏反应可通过长期给予和停用氟哌啶醇而增强；向垂体切除大鼠给予催乳素会部分对抗抗精神病药物诱导的多巴胺受体超敏反应的发展；单独给予催乳素对垂体切除动物的阿扑吗啡诱导行为或神经化学影响最小。这些结果表明，抗精神病药物诱导纹状体多巴胺受体超敏反应不需要垂体分泌（特别是催乳素）的存在；然而，它们确实表明垂体分泌，可能是催乳素，可能具有调节纹状体多巴胺敏感性的能力。
