Morino K, Ohgaki H, Matsukura N, Kawachi T, Sugimura T
IARC Sci Publ. 1982(39):153-6.
The effects of genetic factors on gastrocarcinogenesis in rats were studied by giving 83 micrograms/ml of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the drinking-water to ACI strain rats, Buffalo strain rats, and their F1 hybrid rats for eight months. Animals were sacrificed on the 505th experimental day and examined histologically. The incidences of gastric carcinoma were as follows (no. of carcinoma-bearing rats/no. of effective animals): ACI rats, 86% (12/14) of males and 53% (9/17) of females; Buffalo rats, 19% (3/16) of males and 0% (0/13) of females; F1 hybrids between ACI and Buffalo rats, 23% (7/30) of males and 3% (1/32) of females. The incidence of gastric carcinoma in F1 hybrids was significantly lower than that in ACI rats but not significantly different from that in Buffalo rats. These results suggest that resistance to gastrocarcinogenesis by MNNG is an autosomally dominant trait.
通过给 ACI 品系大鼠、布法罗品系大鼠及其 F1 杂交大鼠饮用含 83 微克/毫升 N-甲基-N'-硝基-N-亚硝基胍（MNNG）的水八个月，研究了遗传因素对大鼠胃癌发生的影响。在实验第 505 天处死动物并进行组织学检查。胃癌发生率如下（患癌大鼠数/有效动物数）：ACI 大鼠，雄性为 86%（12/14），雌性为 53%（9/17）；布法罗大鼠，雄性为 19%（3/16），雌性为 0%（0/13）；ACI 与布法罗大鼠的 F1 杂交种，雄性为 23%（7/30），雌性为 3%（1/32）。F1 杂交种的胃癌发生率显著低于 ACI 大鼠，但与布法罗大鼠无显著差异。这些结果表明，对 MNNG 诱导胃癌的抗性是一种常染色体显性性状。
