Miller K A
J Adolesc Health Care. 1982 Dec;3(3):177-9. doi: 10.1016/s0197-0070(82)80122-8.
Twenty-one chronic asthma patients ages 12 to 17 years were studied to determine their compliance in taking medication. Serum theophylline concentrations were determined and theophylline dosage (milligrams per kilogram body weight per day) was calculated in participants who had allegedly followed their medication regimen. Although the theophylline dosage followed the guidelines in the literature, only 10% of the patients had serum levels in the therapeutic range. This study suggests that noncompliance among adolescent asthmatics is similar to the noncompliance found in adolescents with other chronic illnesses and that physicians should use drug levels in designing optimal short- and long-term management programs. Further, it emphasizes the need for physicians to educate their patients as to the therapeutic actions of the medication they are taking and the necessity of medication compliance.
对21名年龄在12至17岁的慢性哮喘患者进行了研究，以确定他们服药的依从性。测定了血清茶碱浓度，并计算了据称遵循药物治疗方案的参与者的茶碱剂量（每天每千克体重的毫克数）。尽管茶碱剂量符合文献中的指导原则，但只有10%的患者血清水平处于治疗范围内。这项研究表明，青少年哮喘患者的不依从情况与患有其他慢性疾病的青少年的不依从情况相似，医生在设计最佳短期和长期管理方案时应参考药物水平。此外，它强调医生需要教育患者了解他们所服用药物的治疗作用以及药物依从性的必要性。
