Cutts J H, Krause W J
J Anat. 1982 Oct;135(Pt 3):601-13.
The postnatal development of the spleen has been examined in 85 opossums ranging in age from newborn to adult. At birth the spleen consists of a well vascularized mass of mesenchymal tissue and lacks lymphatic tissue or any evidence of haemopoietic activity. Haemopoiesis is evident at seven days, increases to a maximum at about two to three weeks and thereafter gradually declines. Although production of granulocytes has disappeared by 60 days postnatum, a small degree of erythropoiesis and megakaryocyte formation continues throughout life. Lymphatic tissue appears by the third week, but germinal centres do not appear until after weaning. A feature of the spleen during the first three to four days is the presence of a population of primitive 'blast' cells.
对85只从新生到成年的负鼠的脾脏产后发育情况进行了研究。出生时，脾脏由血管丰富的间充质组织团块组成，缺乏淋巴组织或任何造血活动的迹象。造血在7天时明显可见，在大约两到三周时增加到最大值，此后逐渐下降。虽然粒细胞生成在产后60天时消失，但小程度的红细胞生成和巨核细胞形成在整个生命过程中持续存在。淋巴组织在第三周出现，但生发中心直到断奶后才出现。在最初的三到四天里，脾脏的一个特征是存在一群原始的“母细胞”。
