Snyder D S, Greenberg R A
J Invest Dermatol. 1977 Sep;69(3):279-81. doi: 10.1111/1523-1747.ep12507493.
Soft tissue x-ray techniques were used to measure skin thickness as influenced by the chronic usage of topical corticosteroids. In a double-blind study commercial preparations of 1% hydrocortisone (HC), 0.1% triamcinolone acetonide (TA), and a placebo cream were compared for their ability to produce atrophy in normal human forearm skin. After 8 weeks of topical application of the creams, only TA produced clinically apparent atrophy. The average percent decreases in skin thickness measured after 8 weeks of treatment with placebo, HC, or TA were 6.0%, 6.0%, and 17.1%, respectively. During the first week after cessation of treatment the clinical appearance of the skin began to improve and by 1 month all treated skin areas had essentially returned to pretreatment thickness.
采用软组织X射线技术测量长期使用外用皮质类固醇对皮肤厚度的影响。在一项双盲研究中，比较了1%氢化可的松（HC）、0.1%曲安奈德（TA）的商业制剂和一种安慰剂乳膏在正常人类前臂皮肤中产生萎缩的能力。在局部涂抹乳膏8周后，只有TA产生了临床上明显的萎缩。用安慰剂、HC或TA治疗8周后测量的皮肤厚度平均百分比下降分别为6.0%、6.0%和17.1%。在停止治疗后的第一周，皮肤的临床表现开始改善，到1个月时，所有治疗过的皮肤区域基本恢复到治疗前的厚度。
