Balster R L, Moser V C, Woolverton W L
J Pharmacol Methods. 1982 Dec;8(4):299-309. doi: 10.1016/0160-5402(82)90047-x.
A method is described for exposing mice, lever-pressing on an operant schedule for water reinforcement, to continuously-generated solvent vapors. Concurrent monitoring of chamber concentration and schedule-controlled behavior allows a correlation of the magnitude and time course for behavioral effects with changes in the levels of solvent exposure. Data are presented showing the acute effects of 1,1,1-trichloroethane over the range of 1000-8000 ppm on behavior maintained by a fixed-ratio 100 schedule of water presentation. Concentration-dependent decreases in response rates with a rapid onset and recovery were obtained.
本文描述了一种方法，可使按操作性程序压杆以获取水强化的小鼠暴露于持续产生的溶剂蒸气中。同时监测实验箱内的浓度和按程序控制的行为，能够将行为效应的大小和时间进程与溶剂暴露水平的变化联系起来。文中给出的数据显示了1000 - 8000 ppm范围内的1,1,1 - 三氯乙烷对由固定比率100的水呈现程序维持的行为的急性影响。得到了响应率随浓度降低、起效迅速且恢复较快的结果。
