Bowen S E, Balster R L
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, USA.
Exp Clin Psychopharmacol. 1998 Aug;6(3):235-47. doi: 10.1037//1064-1297.6.3.235.
Increases in rates of rodent behavior have been commonly seen with exposure to abused vapors. In the 1st study, 30-min exposures to vapors of toluene, trichloroethane (TCE), or methoxyflurane produced increases in locomotor activity of mice at lower concentrations and decreases at higher concentrations. In the 2nd study, the effects of these vapors on schedule-controlled behavior were determined in mice lever pressing under a multiple fixed-ratio, 20-fixed interval (FI), 3-min schedule. Only concentration-related decreases in response rates were obtained in both components. In the 3rd study, toluene and TCE again produced only decreases in rates of responding under a simple FI 3-min schedule; biphasic effects were produced by methoxyflurane and amyl nitrite. The increases in rates of behavior often seen with abused vapors depend on the testing conditions.
接触滥用性挥发性物质后，啮齿动物行为发生率的增加很常见。在第一项研究中，小鼠接触甲苯、三氯乙烷（TCE）或甲氧氟烷的挥发性物质30分钟，在较低浓度下会使运动活性增加，而在较高浓度下则会降低。在第二项研究中，在多重固定比率、20固定间隔（FI）、3分钟的实验安排下，对按压杠杆的小鼠测定了这些挥发性物质对按计划控制行为的影响。在两个组成部分中均仅获得了与浓度相关的反应率下降。在第三项研究中，甲苯和TCE在简单的3分钟FI实验安排下同样仅使反应率下降；甲氧氟烷和亚硝酸戊酯产生了双相效应。滥用性挥发性物质常出现的行为发生率增加取决于测试条件。
