Bowen S E, Balster R L
Department of Pharmacology & Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613, USA.
Neurotoxicol Teratol. 1996 Jan-Feb;18(1):77-81. doi: 10.1016/0892-0362(95)02024-1.
To quantify the motoric effects of an abused solvent, photocells were added to two exposure systems. The first system utilized a static exposure chamber that recirculated vapor-laden air. A second dynamic system allowed for removal of waste gases with replenishment of fresh air combined with test vapors. In the present studies, male mice were examined for effects on locomotor activity following 30-min inhalation exposures to several concentrations of 1,1,1-trichloroethane (TCE), a widely used and abused solvent. TCE produced significant increases in locomotor activity at intermediate concentrations. Minimally effective concentrations for activity-increasing effects in the dynamic and static systems were 1,250 ppm and 2,500 ppm, respectively. At higher concentrations, motor activity was decreased with the highest dynamic system concentration (10,000 ppm), resulting in 26% of baseline control values. Biphasic, motor activity increasing and decreasing effects of TCE as a function of exposure concentration may reflect the CNS-depressant drug-like effects of abused solvents.
为了量化滥用溶剂的运动效应，在两个暴露系统中添加了光电管。第一个系统使用一个静态暴露室，该室循环充满蒸气的空气。第二个动态系统允许去除废气并补充新鲜空气以及测试蒸气。在本研究中，对雄性小鼠进行了检查，观察其在吸入暴露于几种浓度的1,1,1 - 三氯乙烷（TCE，一种广泛使用和滥用的溶剂）30分钟后对运动活动的影响。TCE在中等浓度下显著增加了运动活动。在动态和静态系统中，产生运动活动增加效应的最低有效浓度分别为1250 ppm和2500 ppm。在较高浓度下，运动活动降低，动态系统的最高浓度（10000 ppm）导致运动活动仅为基线对照值的26%。TCE作为暴露浓度的函数所产生的双相运动活动增加和降低效应，可能反映了滥用溶剂类似中枢神经系统抑制剂的药物效应。
