甲状腺功能与持续性非卧床腹膜透析

Thyroid function and continuous ambulatory peritoneal dialysis.

作者信息

Semple C G, Beastall G H, Henderson I S, Thomson J A, Kennedy A C

出版信息

Nephron. 1982;32(3):249-52. doi: 10.1159/000182854.

Abstract

Thyroid function was evaluated in 16 patients with end-stage renal failure, 8 treated by maintenance haemodialysis (HD) and 8 by continuous ambulatory peritoneal dialysis (CAPD), and compared with 8 healthy subjects. Serum total thyroxine (T4) and triiodothyronine (T3) concentrations were low in both groups (p less than 0.01) with T3 significantly lower in the CAPD than the HD group (p less than 0.01). Serum-free thyroxine (FT4) concentrations were low in CAPD patients with respect to normal (p less than 0.01). Basal thyroid-stimulating hormone (TSH) concentrations did not differ significantly from normal but the TSH responses to thyrotrophin-releasing hormone were depressed in both groups. While CAPD may improve control of some biochemical and haematological parameters as compared with HD, it does not have a beneficial effect on thyroid function.

摘要

对16例终末期肾衰竭患者的甲状腺功能进行了评估，其中8例接受维持性血液透析（HD）治疗，8例接受持续性非卧床腹膜透析（CAPD）治疗，并与8名健康受试者进行了比较。两组患者的血清总甲状腺素（T4）和三碘甲状腺原氨酸（T3）浓度均较低（p<0.01），CAPD组的T3显著低于HD组（p<0.01）。CAPD患者的血清游离甲状腺素（FT4）浓度相对于正常水平较低（p<0.01）。基础促甲状腺激素（TSH）浓度与正常水平无显著差异，但两组患者对促甲状腺激素释放激素的TSH反应均受到抑制。与HD相比，CAPD可能改善了一些生化和血液学参数的控制，但对甲状腺功能没有有益影响。