Ross R J, Goodwin F J, Houghton B J, Boucher B J
Ann Clin Biochem. 1985 Mar;22 ( Pt 2):156-60. doi: 10.1177/000456328502200209.
Pituitary-thyroid function was investigated in 60 patients with chronic renal failure and 18 normal subjects. Serum triiodothyronine and free thyroxine levels were lower in patients treated by either haemodialysis or continuous ambulatory peritoneal dialysis compared with the normal subjects. Serum thyroxine and free thyroxine index were significantly lower in the haemodialysis-treated patients than in the normal subjects. There were no differences in serum thyroxine and free thyroxine index between the continuous ambulatory peritoneal dialysis-treated and normal groups. Serum thyrotrophin was not raised in any of the groups but the serum thyrotrophin response to thyrotrophin-releasing hormone was blunted in both groups of patients. Basal serum prolactin and growth hormone were raised in both groups of patients but there was no significant difference between them. This study confirmed that pituitary-thyroid function is abnormal in patients receiving haemodialysis and established that a similar pattern of abnormalities occurs in patients undergoing continuous ambulatory peritoneal dialysis.
对60例慢性肾衰竭患者和18名正常受试者的垂体 - 甲状腺功能进行了研究。与正常受试者相比，接受血液透析或持续性非卧床腹膜透析治疗的患者血清三碘甲状腺原氨酸和游离甲状腺素水平较低。血液透析治疗的患者血清甲状腺素和游离甲状腺素指数显著低于正常受试者。持续性非卧床腹膜透析治疗组与正常组之间血清甲状腺素和游离甲状腺素指数无差异。所有组的血清促甲状腺激素均未升高，但两组患者对促甲状腺激素释放激素的血清促甲状腺激素反应均减弱。两组患者的基础血清催乳素和生长激素均升高，但两者之间无显著差异。本研究证实接受血液透析的患者垂体 - 甲状腺功能异常，并确定在进行持续性非卧床腹膜透析的患者中也出现类似的异常模式。
