Vogel H P
Pharmacopsychiatria. 1982 Nov;15(6):192-6. doi: 10.1055/s-2007-1019537.
20, not yet severely disabled, drug-free patients with Parkinson's disease were investigated with regard to their motor deficit and mood disturbances. Global scores of depression indicated a high depressive morbidity which did not correlate with the severity of parkinsonism and which could not be adequately explained by physical disability. The apathic syndrome had a close relationship to the severity of parkinsonism. In contrast, the somatic-depressive syndrome did not show such a relationship. Patients predominantly affected by tremor felt subjectively better than the others. These facts demonstrate that it is necessary to break down the complex syndromes of parkinsonism and depression into more elementary dysfunctions in order to evaluate their mutual interdependence.
对20名尚未出现严重残疾、未服用药物的帕金森病患者的运动功能障碍和情绪障碍进行了调查。抑郁的总体评分表明抑郁发病率较高，这与帕金森病的严重程度无关，也不能完全用身体残疾来解释。冷漠综合征与帕金森病的严重程度密切相关。相比之下，躯体抑郁综合征则没有这种关系。以震颤为主的患者主观感觉比其他患者更好。这些事实表明，有必要将帕金森病和抑郁症的复杂综合征分解为更基本的功能障碍，以便评估它们之间的相互依存关系。
