Smith R W, Knight R A, Walsh A
Res Vet Sci. 1982 Nov;33(3):287-9.
The activities (per g of tissue) of hexokinase, phosphofructokinase and pyruvate kinase were unchanged throughout lactation in liver and in kidney cortex. In both these tissues glucose 6-phosphatase activity decreased during late lactation. At the same time fructose diphosphatase activity increased in kidney cortex but not in liver. Activities of the pentose cycle dehydrogenases and of aspartate aminotransferase tended to increase in mid lactation. For most enzymes the activities at peak lactation were similar to those for dry, non-pregnant cows and there was no specific response of the gluconeogenic enzymes. Total hepatic contents of most enzymes tended to increase in mid lactation, but the changes were not clear cut and were the result of an increase in liver size.
在整个哺乳期，肝脏和肾皮质中己糖激酶、磷酸果糖激酶和丙酮酸激酶的活性（每克组织）保持不变。在这两种组织中，葡萄糖6 -磷酸酶活性在哺乳期后期降低。与此同时，肾皮质中的果糖二磷酸酶活性增加，而肝脏中则没有。戊糖循环脱氢酶和天冬氨酸转氨酶的活性在泌乳中期趋于增加。对于大多数酶来说，泌乳高峰期的活性与干奶期、未怀孕奶牛的活性相似，糖异生酶没有特异性反应。大多数酶的肝脏总含量在泌乳中期趋于增加，但变化并不明显，这是肝脏体积增加的结果。
