十一烷酸对红色毛癣菌磷脂代谢的影响
Effect of undecanoic acid on phospholipid metabolism in Trichophyton rubrum.
作者信息
Das S K, Banerjee A B
出版信息
Sabouraudia. 1982 Dec;20(4):267-72.
At its minimum inhibitory concentration, undecanoic acid (UDA) inhibits biosynthesis of phosphatidyl serine, phosphatidyl ethanolamine and polyphosphoinositol but does not inhibit the synthesis of phosphatidyl glycerol, phosphatidyl choline, phosphatidyl inositol and phosphatidic acid in Trichophyton rubrum. At higher concentration, however UDA inhibits biosynthesis of all phosphatides present in this dermatophyte. UDA also affects catabolism of these phosphatides. This inhibitory effect of UDA may be partially responsible for its toxic action on T. rubrum.
在其最低抑菌浓度下，十一烷酸（UDA）可抑制红色毛癣菌中磷脂酰丝氨酸、磷脂酰乙醇胺和多磷酸肌醇的生物合成，但不抑制磷脂酰甘油、磷脂酰胆碱、磷脂酰肌醇和磷脂酸的合成。然而，在较高浓度下，UDA会抑制这种皮肤癣菌中所有磷脂的生物合成。UDA还会影响这些磷脂的分解代谢。UDA的这种抑制作用可能部分解释了其对红色毛癣菌的毒性作用。
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