Hietanen E, Aitio A, Koivusaari U, Kilpiö J, Nevalainen T, Närhi M, Savolainen H, Vainio H
Toxicology. 1982;25(2-3):113-27. doi: 10.1016/0300-483x(82)90023-3.
Adult male rabbits were exposed to lead (0.2%), zinc (0.5%) or to both lead and zinc (0.2% and 0.5%) which were given in the drinking water as acetates for 2 weeks or 4 weeks. Blood lead levels in lead exposed rabbits were about 15-fold in comparison with the controls after 2 weeks exposure and remained at this level after further exposure, but when zinc was given with lead the blood lead level doubled from 2 weeks to 4 weeks. In rabbits having both lead and zinc, the cerebral lead concentration was much lower than in rabbits exposed only to the respective amount of lead. No such effect was found in the cerebellum or sciatic nerve. Zinc did not prevent lead accumulation in the parenchymal tissues. Only a rather low induction of drug metabolizing enzyme activities was found in the liver of lead-exposed rabbits and zinc did not modify this induction. The results suggest that, although zinc might delay the lead accumulation in the cerebrum, it has little value in preventing peripheral neuropathy or metabolic alterations caused by lead.
成年雄性兔子被暴露于铅（0.2%）、锌（0.5%）或铅与锌（0.2%和0.5%）中，这些铅和锌以醋酸盐的形式添加到饮用水中，持续2周或4周。暴露于铅的兔子在暴露2周后，其血铅水平相较于对照组约高15倍，进一步暴露后仍维持在该水平，但当锌与铅同时给予时，血铅水平从2周时到4周翻倍。在同时接触铅和锌的兔子中，大脑中的铅浓度远低于仅暴露于相应剂量铅的兔子。在小脑或坐骨神经中未发现此类影响。锌并不能阻止铅在实质组织中的蓄积。在暴露于铅的兔子肝脏中仅发现药物代谢酶活性有相当低程度的诱导，锌并未改变这种诱导作用。结果表明，尽管锌可能会延缓铅在大脑中的蓄积，但在预防由铅引起的周围神经病变或代谢改变方面价值不大。
