Ogata M, Shimada Y
Acta Med Okayama. 1982 Dec;36(6):491-4. doi: 10.18926/AMO/30672.
Differences in urinary excretion of monochlorobenzene between rats and humans were studied. Monochlorobenzene was administered to rats and humans intraperitoneally, orally or by inhalation. Urinary p-chlorophenylmercapturic acid and 4-chlorocatechol, after hydrolysis of its conjugate, were measured. The excretion of p-chlorophenylmercapturic acid was somewhat more than that of 4-chlorocatechol in rats which were administered monochlorobenzene orally or intraperitoneally. The excretion of p-chlorophenylmercapturic acid was markedly less than that of 4-chlorocatechol in humans who received monochlorobenzene orally or by inhalation. The results indicate that the 4-chlorocatechol conjugate is a suitable index of metabolites in the urine of workers exposed to monochlorobenzene.
研究了大鼠和人类之间一氯苯尿排泄的差异。将一氯苯通过腹腔注射、口服或吸入的方式给予大鼠和人类。测定尿中对氯苯基巯基尿酸及其结合物水解后的4-氯邻苯二酚。在经口或腹腔注射给予一氯苯的大鼠中，对氯苯基巯基尿酸的排泄量略多于4-氯邻苯二酚。在经口或吸入给予一氯苯的人类中，对氯苯基巯基尿酸的排泄量明显少于4-氯邻苯二酚。结果表明，4-氯邻苯二酚结合物是接触一氯苯工人尿液中代谢物的合适指标。
