Department of Mechanical Engineering, Hanyang University, Seoul, Korea.
Inhal Toxicol. 2012 Aug;24(9):550-6. doi: 10.3109/08958378.2012.696742. Epub 2012 Jul 19.
In this study, a direct-flow-type nose-only exposure chamber developed for inhalation toxicity experiments using a numerical analysis and experiments is evaluated. Maintaining a uniform flow rate and test article concentration are the critical factors when designing an inhalation exposure chamber. Therefore, this study evaluated whether the flow rate and particle size distribution at the injection nozzles at each port could be maintained with a deviation below 10%. To achieve this requirement, a nose-only exposure chamber flow field was simulated using a numerical analysis method, i.e. computational fluid dynamics (CFD) code FLUENT 6.3.26. Based on the simulation results, a test chamber was built and tested. The flow velocity was measured at the injection nozzle of the chamber and the aerosol particle size distribution was also measured at each port while inserting the test material into the exposure chamber. The results indicated that a uniform flow field distribution at each stage and port, the deviation of the flow velocity, and particle size distribution were all within 10%. Thus, the resulting nose-only exposure chamber could be described as well-designed.
在这项研究中，评估了一种用于吸入毒性实验的直通式鼻式暴露室，该暴露室是通过数值分析和实验开发的。在设计吸入暴露室时，维持均匀的流速和测试物浓度是关键因素。因此，本研究评估了在每个端口的注射喷嘴处的流速和粒径分布是否可以在 10%以下的偏差内保持。为了实现这一要求，使用数值分析方法，即计算流体动力学（CFD）代码 FLUENT 6.3.26，对鼻式暴露室流场进行了模拟。基于模拟结果，构建并测试了一个测试室。在将测试材料插入暴露室时，测量了腔室的注射喷嘴处的流速，并且还测量了每个端口处的气溶胶粒径分布。结果表明，每个阶段和端口的流场分布均匀，流速和粒径分布的偏差均在 10%以内。因此，可以将得到的鼻式暴露室描述为设计良好。
