Leroy J P, Volant A, Guedes Y, Briere J
Ann Pathol. 1982;2(4):332-5.
The authors report a case of a forty-years-old woman who died nineteen hours after ingestion of a massive dose of Paraquat (about 125 ml of Gramoxone, 52 g of Paraquat) with vomitings, anuria and cardiac arrest. Early autopsy (less than two hours after death) showed necrotizing esophagitis, ulcerative gastritis, tubular nephritis, congestion of lung, interstitial myocarditis which could explain the heart failure. The ultrastructural study of lung showed interstitial edema associated with minimal endothelial changes but important epithelial cell necrosis of both pneumocytes. These findings are very similar to experimental studies of massive Paraquat poisoning emphasizing the early involvement of pneumocyte II.
作者报告了一例40岁女性病例，该女性在摄入大量百草枯（约125毫升克无踪，52克百草枯）后19小时死亡，伴有呕吐、无尿和心脏骤停。早期尸检（死亡后不到两小时）显示坏死性食管炎、溃疡性胃炎、肾小管肾炎、肺充血、间质性心肌炎，这些可解释心力衰竭。肺的超微结构研究显示间质水肿，伴有轻微的内皮细胞变化，但两种肺细胞的上皮细胞均有重要坏死。这些发现与大量百草枯中毒的实验研究非常相似，强调了II型肺细胞的早期受累。
