Pons M, Johnston D S, Chapman D
Biochim Biophys Acta. 1982 Dec 22;693(2):461-5. doi: 10.1016/0005-2736(82)90454-0.
Phospholipids (phosphatidylcholines) which contain a diacetylene group in a single acyl chain and within both acyl chains have been synthesized. Upon irradiation with ultraviolet light, both types of lipid crosslink via the diacetylene groups to produce coloured polymers. The colour arises from the conjugated double and triple bonds which make up the polymer backbone. These phospholipid polymers can exhibit optical activity, as shown by their circular dichroic spectra. The optical activity is thought to stem from asymmetric packing of the polydiacetylene chains, a packing of one particular screw sense being favoured by the chiral glycerol moiety of the lipid. The presence of an intrinsic membrane protein within the liposome structure affects the CD spectra of polymer produced by irradiation.
已合成了在单个酰基链中以及在两个酰基链内均含有二乙炔基团的磷脂（磷脂酰胆碱）。在用紫外光照射时，这两种类型的脂质都会通过二乙炔基团发生交联以生成有色聚合物。颜色源自构成聚合物主链的共轭双键和三键。这些磷脂聚合物可表现出光学活性，如它们的圆二色光谱所示。据认为，光学活性源于聚二乙炔链的不对称堆积，脂质的手性甘油部分有利于一种特定螺旋方向的堆积。脂质体结构中内在膜蛋白的存在会影响照射产生的聚合物的圆二色光谱。
