Albrecht O, Johnston D S, Villaverde C, Chapman D
Biochim Biophys Acta. 1982 May 7;687(2):165-9. doi: 10.1016/0005-2736(82)90542-9.
Phospholipids (phosphatidylcholines) with diacetylene in each acyl chain have been deposited in Langmuir-Blodgett multilayers on a variety of substrates. Upon irradiation the diacetylene groups polymerise and link the phospholipid molecules together with a conjugated chain made up of alternating single, double and triple bonds. Advantage has been taken of this polymerisation process to increase the stability of these lipids layers and to produce stable biomembrane hydrophilic surface. These surfaces may be useful for studies of blood coagulation and protein adsorption. In addition they could also have medical application.
在每个酰基链中含有二乙炔的磷脂(磷脂酰胆碱)已被沉积在各种基质上的朗缪尔-布洛杰特多层膜中。经辐照后,二乙炔基团发生聚合,将磷脂分子与由单键、双键和三键交替组成的共轭链连接在一起。利用这一聚合过程提高了这些脂质层的稳定性,并产生了稳定的生物膜亲水性表面。这些表面可能有助于血液凝固和蛋白质吸附的研究。此外,它们还可能具有医学应用价值。