Bujan Ariana, Del Valle Alonso Silvia, Chiaramoni Nadia S
Laboratorio de BioNanotecnología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Buenos Aires, Argentina.
CONICET - Facultad de Ciencias Exactas, Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Universidad Nacional de La Plata, Buenos Aires, Argentina.
Biophys Rev. 2024 Aug 31;16(6):773-782. doi: 10.1007/s12551-024-01221-6. eCollection 2024 Dec.
Synthetic lipids have been studied as components in membrane models and drug delivery systems. Polymerizable phospholipids, especially photosensitive ones, can form new bilayer bonds when UV light irradiates. These phospholipids have been known since the 1980s, but in the last few years, new applications have been highlighted. Its use in drug delivery systems is interesting since the photopolymerization reaction produces highly stable vesicles. Additionally, the rearrangement of the acyl chains during the photopolymerization process can be applied in the generation of pores, resulting in systems that serve for drug-controlled release. In this article, our goal was to envision earlier photopolymers' publications towards the implications of these versatile phospholipids that led to proposed systems for drug delivery and controlled release of drugs at specific sites. This review offers a broad background towards a simple, reliable, and robust platform to make its application available.
合成脂质已作为膜模型和药物递送系统的成分进行了研究。可聚合磷脂，尤其是光敏性磷脂，在紫外线照射时可形成新的双层键。这些磷脂自20世纪80年代就已为人所知，但在过去几年中，新的应用受到了关注。其在药物递送系统中的应用很有意思，因为光聚合反应会产生高度稳定的囊泡。此外，光聚合过程中酰基链的重排可应用于孔的生成，从而产生用于药物控释的系统。在本文中，我们的目标是回顾早期光聚合物的出版物，探讨这些多功能磷脂的影响，这些影响促成了用于药物递送和特定部位药物控释的系统。这篇综述为构建一个简单、可靠且强大的应用平台提供了广泛的背景知识。
