Houghton E, Teale P, Dumasia M C, Wellby J K
Biomed Mass Spectrom. 1982 Nov;9(11):459-65. doi: 10.1002/bms.1200091102.
The negative ion chemical ionization mass spectra of the MO-TMS derivatives of the corticosteroids prednisolone, betamethasone and dexamethasone have been obtained using capillary column gas chromatography mass spectrometry. The spectra showed abundant diagnostic ions at m/z greater than 300 allowing for clear discrimination between the three steroid derivatives. A capillary column gas chromatographic mass spectrometric method using negative ion chemical ionization mass spectrometry has been developed to confirm the presence of the parent steroids in horse urine following the administration of proprietary preparations of prednisolone and betamethasone.
使用毛细管柱气相色谱 - 质谱联用技术获得了皮质类固醇泼尼松龙、倍他米松和地塞米松的MO - TMS衍生物的负离子化学电离质谱。该质谱在m/z大于300处显示出丰富的诊断离子，从而能够清晰地区分这三种类固醇衍生物。已开发出一种使用负离子化学电离质谱的毛细管柱气相色谱 - 质谱联用方法，用于在给予泼尼松龙和倍他米松的专利制剂后，确认马尿中母体类固醇的存在。
