Krause U
Chemotherapy. 1982;28 Suppl 1:99-105. doi: 10.1159/000238161.
212 patients with cultural evidence of yeast-induced vaginal mycosis were treated with a single vaginal tablet of 500 mg clotrimazole. A diagnosis of infection due to a Candida species had been established before therapy in 95% of the patients studied. From the total group of 212 patients a further group was formed who had appeared at the check-ups as scheduled in the trial protocol and whose data were complete. This group included 83 cases. There was no therapeutic difference between the two patient groups. 89% of the patients of the total patient group evaluable were found to be mycologically cured at both check-ups. In the reduced patient group the rates of mycological cure at the times of examination were 87 and 89%, respectively. The clinical results obtained in the total patient group indicated a therapeutic success of 90% at both check-ups. In the reduced patient group the rate of therapeutic success was 93% at the first and 88% at the second check-up. The local tolerability of the Canesten vaginal tablet was good. The side effects observed were rare and mild.
212例有酵母菌引起的阴道真菌病培养证据的患者接受了一片500毫克克霉唑阴道片的治疗。在95%的研究患者中，治疗前已确诊为念珠菌属感染。从212例患者的总群体中，又形成了一组按照试验方案如期进行检查且数据完整的患者。该组包括83例。两组患者之间没有治疗差异。在可评估的总患者群体中，89%的患者在两次检查时真菌学上均已治愈。在缩减后的患者组中，检查时的真菌学治愈率分别为87%和89%。在总患者群体中获得的临床结果表明，两次检查时的治疗成功率均为90%。在缩减后的患者组中，第一次检查时的治疗成功率为93%，第二次检查时为88%。凯妮汀阴道片的局部耐受性良好。观察到的副作用很少且轻微。
