Lazarus S S, Trombetta L D
Histopathology. 1982 Nov;6(6):793-805. doi: 10.1111/j.1365-2559.1982.tb02775.x.
An ultrastructural and histochemical analysis was made of a lesion identified by light microscopy as a non-ossifying fibroma of bone. A histogenetic sequence was traced from spindle-shaped fibroblast-like cells to multivacuolated lipoblasts with abundant glycogen. These lipid-laden cells showed remarkable similarity to some cells of a well differentiated liposarcoma. Others have interpreted the lipid-containing cells of non-ossifying fibroma as representing fibroblasts which have imbibed or synthesized lipid or lipid-laden macrophages. Our studies demonstrate that this tumour consists of primitive mesenchymal cells with partial maturation to early lipoblasts, suggesting its classification as a benign lipoblastoma of bone.
对经光学显微镜鉴定为骨非骨化性纤维瘤的病变进行了超微结构和组织化学分析。追踪了从梭形成纤维细胞样细胞到富含糖原的多空泡脂肪母细胞的组织发生序列。这些充满脂质的细胞与高分化脂肪肉瘤的一些细胞表现出显著相似性。其他人将非骨化性纤维瘤中含脂质的细胞解释为吸收或合成了脂质的成纤维细胞或充满脂质的巨噬细胞。我们的研究表明，这种肿瘤由原始间充质细胞组成，部分成熟为早期脂肪母细胞，提示将其分类为骨良性脂肪母细胞瘤。
