Bolen J W, Thorning D
Am J Surg Pathol. 1980 Apr;4(2):163-74. doi: 10.1097/00000478-198004000-00008.
A benign lipoblastoma and a myxoid liposarcoma were studied by light and electron microscopy. Both of these neoplasms had prominent plexiform vascular networks, early acquisition of fat by vascular pericytes, and progressive accumulation of fat by cells located away from the vasculature. Their component cells had investing basal laminae, pinocytotic vesicles, and cytoplasmic glycogen stores as well as cytoplasmic lipid. The process of neoplastic lipogenesis and the structural features of the neoplastic cells in both neoplasms resembled those of developing non-neoplastic fat tissue. The benign lipoblastoma appears to be analogous to developing fat, while the myxoid liposarcoma appears to recapitulate the actively proliferating zone of developing fat. The relationship between proliferating cells and the plexiform vascular network in all three processes is emphasized. We hypothesize that the vascular pericyte serves as a source for new fat storing cells.
通过光学显微镜和电子显微镜对一例良性脂肪母细胞瘤和一例黏液样脂肪肉瘤进行了研究。这两种肿瘤均具有显著的丛状血管网络，血管周细胞早期获取脂肪，且远离血管的细胞脂肪逐渐蓄积。其组成细胞具有包绕性基底膜、吞饮小泡、细胞质糖原储存以及细胞质脂质。两种肿瘤中的肿瘤性脂肪生成过程和肿瘤细胞的结构特征与发育中的非肿瘤性脂肪组织相似。良性脂肪母细胞瘤似乎类似于发育中的脂肪，而黏液样脂肪肉瘤似乎重现了发育中脂肪的活跃增殖区。强调了在所有三个过程中增殖细胞与丛状血管网络之间的关系。我们推测血管周细胞是新的脂肪储存细胞的来源。
