位于第7号染色体上的Ly-21.2基因的精确图谱绘制。
Precise mapping of the gene for Ly-21.2 on the 7th chromosome.
作者信息
Kennard J, Meruelo D
出版信息
J Immunogenet. 1982 Dec;9(6):389-95. doi: 10.1111/j.1744-313x.1982.tb01000.x.
We have recently described a murine lymphocyte alloantigen, Ly-21.2, and showed that the gene which controls Ly-21.2 expression is linked to albinism on the 7th chromosome. In order to map the gene more precisely, we have studied the linkage of Ly-21.2 with two other genetic markers on the 7th chromosome, the electrophoretic variant of the beta chain of haemoglobin and glucose phosphate isomerase, in (A/J x C57BL/10)F2 mice. The results of these 3-point cross studies show that the gene encoding Ly-21.2 maps 27 units distal to albinism.
我们最近描述了一种小鼠淋巴细胞同种抗原Ly-21.2，并表明控制Ly-21.2表达的基因与第7号染色体上的白化病基因相连。为了更精确地定位该基因，我们在（A/J×C57BL/10）F2小鼠中研究了Ly-21.2与第7号染色体上的另外两个遗传标记——血红蛋白β链的电泳变体和葡萄糖磷酸异构酶之间的连锁关系。这些三点杂交研究的结果表明，编码Ly-21.2的基因位于白化病基因远端27个单位处。
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