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通过测定脑脊液中的S-100蛋白评估中枢神经系统损伤。

Assessment of damage to the central nervous system by determination of S-100 protein in the cerebrospinal fluid.

作者信息

Sindic C J, Chalon M P, Cambiaso C L, Laterre E C, Masson P L

出版信息

J Neurol Neurosurg Psychiatry. 1982 Dec;45(12):1130-5. doi: 10.1136/jnnp.45.12.1130.

DOI:10.1136/jnnp.45.12.1130
PMID:7161607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC491696/
Abstract

S-100 protein was determined by Particle Counting ImmunoAssay in the CSF of patients with various neurological disorders. With a limit of sensitivity of 2.5 micrograms/l this brain-specific protein was detected only in samples from patients with acute damage of the central nervous system, particularly in compression of the spinal cord by tumour, ischaemic disorders, subarachnoïd bleeding and haematoma, and viral or suspected viral infections. Our results support the assumption that S-100 is a reliable index of central nervous system damage and that changes in its concentration could have a prognostic value.

摘要

采用颗粒计数免疫分析法测定了各种神经系统疾病患者脑脊液中的S-100蛋白。该脑特异性蛋白的检测灵敏度极限为2.5微克/升，仅在中枢神经系统急性损伤患者的样本中检测到，特别是在肿瘤压迫脊髓、缺血性疾病、蛛网膜下腔出血和血肿以及病毒或疑似病毒感染患者的样本中。我们的结果支持以下假设：S-100是中枢神经系统损伤的可靠指标，其浓度变化可能具有预后价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f17/491696/e38d52a2cd6d/jnnpsyc00056-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f17/491696/e38d52a2cd6d/jnnpsyc00056-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f17/491696/e38d52a2cd6d/jnnpsyc00056-0053-a.jpg

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本文引用的文献

1
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Nature. 1980 Jul 24;286(5771):400-1. doi: 10.1038/286400a0.
2
The S-100 antigen in cerebrospinal fluid as a possible index of cell injury in the nervous system.脑脊液中的S-100抗原作为神经系统细胞损伤的一种可能指标。
J Neurol Sci. 1980 Jan;44(2-3):259-63. doi: 10.1016/0022-510x(80)90133-1.
3
Immunochemical and immuno-cytochemical localization of S-100 antigen in normal human skin.S-100抗原在正常人体皮肤中的免疫化学和免疫细胞化学定位
Graefes Arch Clin Exp Ophthalmol. 2005 Nov;243(11):1167-74. doi: 10.1007/s00417-005-1175-0. Epub 2005 May 20.
4
Cerebrospinal fluid S-100 protein levels in neurological pathologies.
J Physiol Biochem. 2003 Dec;59(4):255-61. doi: 10.1007/BF03179882.
5
Serum S100B protein levels are correlated with subclinical neurocognitive declines after carotid endarterectomy.血清S100B蛋白水平与颈动脉内膜切除术后的亚临床神经认知功能下降相关。
Neurosurgery. 2001 Nov;49(5):1076-82; discussion 1082-3. doi: 10.1097/00006123-200111000-00010.
6
Intraoperative values of S-100 protein, myelin basic protein, lactate, and albumin in the CSF and serum of neurosurgical patients.神经外科患者脑脊液和血清中S-100蛋白、髓鞘碱性蛋白、乳酸和白蛋白的术中值。
J Neurol Neurosurg Psychiatry. 2001 Nov;71(5):671-4. doi: 10.1136/jnnp.71.5.671.
7
Cerebrospinal fluid analysis differentiates between relapsing-remitting and secondary progressive multiple sclerosis.脑脊液分析可区分复发缓解型多发性硬化症和继发进展型多发性硬化症。
J Neurol Neurosurg Psychiatry. 1997 Oct;63(4):446-51. doi: 10.1136/jnnp.63.4.446.
8
Clinico-pathophysiological features of acute autonomic and sensory neuropathy: a long-term follow-up study.
J Neurol. 1995 Oct;242(10):623-8. doi: 10.1007/BF00866911.
9
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J Neurol Neurosurg Psychiatry. 1995 Jul;59(1):103-4. doi: 10.1136/jnnp.59.1.103-a.
10
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Acta Neurochir (Wien). 1988;93(3-4):116-22. doi: 10.1007/BF01402892.
Nature. 1981 Nov 5;294(5836):85-7. doi: 10.1038/294085a0.
4
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5
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6
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Eur J Biochem. 1981 Apr;115(3):469-74. doi: 10.1111/j.1432-1033.1981.tb06225.x.
7
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8
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Dev Neurosci. 1981;4(1):66-78. doi: 10.1159/000112742.
10
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J Neurocytol. 1980 Dec;9(6):771-82. doi: 10.1007/BF01205018.