Lahnborg G, Hedström K G, Nord C E
J Reticuloendothel Soc. 1982 Nov;32(5):347-53.
Glucan, a beta-1-3-polyglucosidic component of the cell wall of Saccharomyces cervisiae, was evaluated for its ability to influence the survival rate in rats with induced intraabdominal sepsis. To mimic closely the human bacteriological intestinal flora, the rats, in 4 groups each of 15 animals, were fed a lean meat diet. Intraabdominal sepsis was induced by resecting 1 cm of the intestine and reimplanting it in the abdominal cavity, reestablishing intestinal continuity by one-layer end-to-end anastomosis. The rats were injected with glucan, isovolumetric saline, and ampicillin or glucan plus ampicillin. The results indicate a significant decrease in mortality in the group treated with ampicillin compared with the group treated with saline only. The group treated with glucan plus ampicillin differed significantly from the group given ampicillin. The bacterial flora was not qualitatively influenced by glucan administration. It is concluded that glucan, in combination with ampicillin, has a significant effect on the survival rate of rats with induced peritonitis, probably by enhancing the activities of the reticuloendothelial system--an important part of the total host resistance.
葡聚糖是酿酒酵母细胞壁的一种β-1,3-多聚葡糖苷成分，研究了其对诱导性腹腔内脓毒症大鼠存活率的影响。为了紧密模拟人类肠道细菌菌群，将大鼠分为4组，每组15只，喂食瘦肉饮食。通过切除1厘米肠段并将其重新植入腹腔，采用单层端端吻合重建肠道连续性来诱导腹腔内脓毒症。给大鼠注射葡聚糖、等体积生理盐水、氨苄青霉素或葡聚糖加氨苄青霉素。结果表明，与仅用生理盐水治疗的组相比，用氨苄青霉素治疗的组死亡率显著降低。用葡聚糖加氨苄青霉素治疗的组与给予氨苄青霉素的组有显著差异。给予葡聚糖对细菌菌群的性质没有影响。得出的结论是，葡聚糖与氨苄青霉素联合使用对诱导性腹膜炎大鼠的存活率有显著影响，可能是通过增强网状内皮系统的活性——这是宿主总抵抗力的一个重要部分。
