Brolin J, Lahnborg G, Nord C E
Acta Chir Scand. 1984;150(3):239-44.
In order to study the effect of one preoperative dosage of antibiotic on the mortality rate, incidence of abscesses, adhesions and intraperitoneal fluid, a previously described reproducible experimental model of intraabdominal infections in rats has been used. Preoperatively, the rats were fed with lean ground beef for two weeks in order to change the intestinal microflora into a microflora similar to humans. The antibiotics tested were: doxycycline (1 mg), cefoxitin (40 mg), tinidazole (8 mg) + netilmicin (5 mg), clindamycin (150 mg) + netilmicin (5 mg) and trimethoprimsulfa (76.8 mg) + tinidazole (8 mg). The results indicate that one preoperative dosage of the antibiotic(s) significantly reduces the mortality rate in rats with intraabdominal sepsis. Intraperitoneal fluid was observed in all non-surviving rats, whereas in the surviving animals no fluid was present regardless of the type of antibiotic. The rate of intraabdominal abscesses was significantly higher in the doxycycline group compared with the other treated groups, indicating an inadequate anaerobic cover of doxycycline. The incidence of intraabdominal postoperative adhesions was similar in all groups except the trimethoprimsulfa + tinidazole group, which had a significantly lower number of rats with adhesions.
为研究术前单次使用抗生素对死亡率、脓肿发生率、粘连及腹腔积液的影响，采用了先前描述的可重复的大鼠腹腔感染实验模型。术前，给大鼠喂食瘦牛肉末两周，以便将肠道微生物群转变为类似人类的微生物群。所测试的抗生素有：强力霉素（1毫克）、头孢西丁（40毫克）、替硝唑（8毫克）+奈替米星（5毫克）、克林霉素（150毫克）+奈替米星（5毫克）以及甲氧苄啶磺胺（76.8毫克）+替硝唑（8毫克）。结果表明，术前单次使用抗生素能显著降低腹腔脓毒症大鼠的死亡率。在所有未存活的大鼠中均观察到腹腔积液，而在存活的动物中，无论使用何种抗生素均未发现积液。与其他治疗组相比，强力霉素组的腹腔脓肿发生率显著更高，这表明强力霉素对厌氧菌的覆盖不足。除甲氧苄啶磺胺+替硝唑组外，所有组术后腹腔粘连的发生率相似，该组粘连大鼠的数量显著更少。
