死后血液标本中巴比妥类药物的气相色谱筛查与确证
GLC screening and confirmation of barbiturates in post mortem blood specimens.
作者信息
Budd R D, Mathis D F
出版信息
J Anal Toxicol. 1982 Nov-Dec;6(6):317-20. doi: 10.1093/jat/6.6.317.
PMID:7162144
Abstract
A quantitative gas chromatographic (GC) method for the screening and confirmation of barbiturates in post mortem blood specimens is presented. Barbiturates were extracted from blood samples and the extracts cleaned-up, concentrated, and then analyzed as free drugs on a 10% UCW-982 GC column. Samples screened positive for free barbiturates were methylated to form 1,3-dimethylbarbiturates, which were then chromatographed on a 3% SE-30 column to confirm the barbiturate identity.
摘要
本文介绍了一种用于筛查和确证死后血液样本中巴比妥类药物的定量气相色谱（GC）方法。从血液样本中提取巴比妥类药物，提取物经过净化、浓缩，然后作为游离药物在10% UCW - 982气相色谱柱上进行分析。游离巴比妥类药物筛查呈阳性的样本进行甲基化反应形成1,3 - 二甲基巴比妥酸盐，然后在3% SE - 30柱上进行色谱分析以确证巴比妥类药物的身份。
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