Ingram D K, Reynolds M A, Les E P
Mech Ageing Dev. 1982 Nov;20(3):253-66. doi: 10.1016/0047-6374(82)90092-6.
Data from nine inbred and six hybrid mouse strains of both sexes were used in a correlational analysis to examine the relationships between lifespan and several growth parameters, including body weight at weaning, at 6 weeks after weaning, and at 1 year, and estimates of growth rate, food consumption, and feeding efficiency during early life. The analysis revealed strong relationships of genotype to all variables. Hybridization was associated with longer lifespan, but sex was not related to lifespan. Several growth parameters were significantly related to lifespan, but the directions of the correlations were sex-dependent. Several body weight and growth parameters were positively correlated to lifespan in males, while negatively correlated to lifespan in females. Genotype accounted for most of the variance in these relationships with the exception of hybrid males, where the correlation between growth rate and lifespan was attributable largely to environmental factors. In demonstrating significant correlations between lifespan and constitutional variables within a species, the results supported a morphogenetically based hypothesis of lifespan inheritance; however, the sex differential in the direction of the relationship between growth and lifespan further demonstrated the difficulty of making predictions deduced from the hypothesis.
来自9个近交系和6个杂交系的雌雄小鼠的数据用于相关性分析，以检验寿命与几个生长参数之间的关系，这些参数包括断奶时、断奶后6周和1岁时的体重，以及早期生活中的生长速率、食物消耗和喂养效率估计值。分析揭示了基因型与所有变量之间的强相关性。杂交与更长的寿命相关，但性别与寿命无关。几个生长参数与寿命显著相关，但相关方向因性别而异。几个体重和生长参数在雄性中与寿命呈正相关，而在雌性中与寿命呈负相关。除了杂交雄性外，基因型在这些关系中占了大部分变异，在杂交雄性中，生长速率与寿命之间的相关性很大程度上归因于环境因素。在证明一个物种内寿命与体质变量之间存在显著相关性时，结果支持了基于形态发生学的寿命遗传假说；然而，生长与寿命之间关系方向上的性别差异进一步证明了从该假说推导预测的困难。
