Mens W B, Andringa-Bakker E A, Van Wimersma Greidanus T B
Neurosci Lett. 1982 Dec 23;34(1):51-6. doi: 10.1016/0304-3940(82)90091-x.
Levels of arginine-vasopressin (AVP) and oxytocin (OXT) in cerebrospinal fluid (CSF) of rats were determined at various times of the day and the night under normal and changed light-dark conditions. During a regular daily 14 h light and 10 h dark cycle (lights on 06.00 h, off 20.00 h), AVP in CSF reached a peak at 13.00 h, while the lowest levels were found at 19.00 h. Reversal of the normal light-dark cycle into a 14 h dark and 10 h light cycle (lights on 20.00 h, off 06.00 h) did not change the normal AVP rhythm. These lighting conditions elevated the OXT levels in the CSF as compared to those found during a normal light-dark regime, but again no differences were observed between the OXT levels determined at the various time-points. A shift of 6 h of the light-dark cycle (lights on 12.00 h, lights off 02.00 h), completely disrupted the AVP rhythm. However, after 3 weeks of adaptation to this new light-dark regime a high level of AVP in CSF was again observed at 13.00 h, and a low level at 19.00 h. The present data suggest that changes in the normal light-dark conditions affect the levels of neurohypophyseal peptides in the CSF. The results are of interest because of reported changes in memory function induced by alterations in the light-dark cycle.
在正常和改变的明暗条件下，于一天中的不同时间点测定大鼠脑脊液（CSF）中精氨酸加压素（AVP）和催产素（OXT）的水平。在日常规律的14小时光照和10小时黑暗周期（06:00开灯，20:00关灯）期间，脑脊液中的AVP在13:00达到峰值，而在19:00发现最低水平。将正常的明暗周期颠倒为14小时黑暗和10小时光照周期（20:00开灯，06:00关灯）并未改变正常的AVP节律。与正常明暗状态下相比，这些光照条件提高了脑脊液中的OXT水平，但在各个时间点测定的OXT水平之间再次未观察到差异。将明暗周期提前6小时（12:00开灯，02:00关灯），完全打乱了AVP节律。然而，在适应这种新的明暗状态3周后，在13:00再次观察到脑脊液中AVP水平较高，而在19:00水平较低。目前的数据表明，正常明暗条件的变化会影响脑脊液中神经垂体肽的水平。由于据报道明暗周期改变会引起记忆功能变化，这些结果很有趣。
