Jolkkonen J, Tuomisto L, van Wimersma Greidanus T B, Läärä E, Riekkinen P J
Neuroendocrinology. 1986;44(2):163-7. doi: 10.1159/000124640.
In male and female rats of two different age groups, we measured the arginine-vasopressin (AVP) levels in cerebrospinal fluid (CSF) collected at different times of the day. Mean values of AVP in cisternal CSF averaged across the different times of the day were higher in males than in females (p = 0.02), and in young (2 months) than in aged (12 months) rats (p = 0.03) of both sexes. The AVP levels in CSF showed a clear circadian rhythm in both young and aged male rats; the values at 07.00 h and 13.00 h were higher than those at 01.00 h and 19.00 h. The amplitude of the rhythm was smaller in females than in males. In addition, the rhythm was more pronounced in young than in aged rats of both sexes. These data suggest that both age and sex affect levels of vasopressin in CSF.
在两个不同年龄组的雄性和雌性大鼠中，我们测量了在一天中不同时间采集的脑脊液（CSF）中的精氨酸加压素（AVP）水平。跨一天不同时间平均的脑池CSF中AVP的平均值，雄性高于雌性（p = 0.02），且在两个性别的年轻（2个月）大鼠中高于老年（12个月）大鼠（p = 0.03）。年轻和老年雄性大鼠CSF中的AVP水平均呈现明显的昼夜节律；07:00和13:00的值高于01:00和19:00的值。雌性的节律幅度小于雄性。此外，在两个性别的年轻大鼠中，节律比老年大鼠更明显。这些数据表明年龄和性别都会影响CSF中加压素的水平。
