食品黄酮醇槲皮素的体内非诱变性

Nonmutagenicity in vivo of the food flavonol quercetin.

作者信息

Aeschbacher H U, Meier H, Ruch E

出版信息

Nutr Cancer. 1982;4(2):90-8. doi: 10.1080/01635588209513744.

DOI:10.1080/01635588209513744

Abstract

Mice given quercetin per os at concentrations that were about 10(3) times greater than the estimated average human intake of total flavonols were tested for mutagenicity with 2 complementary in vivo mutagenicity/carcinogenicity screening tests--the micronucleus test and the host-mediated assay employing the Ames Salmonella tester strain TA 98 as indicator organism. No mutagenic effect was detected with either test.

摘要

给小鼠经口给予槲皮素，其浓度约比估计的人类总黄酮醇平均摄入量高10³倍，然后用两种互补的体内诱变性/致癌性筛选试验——微核试验和以鼠伤寒沙门氏菌测试菌株TA 98作为指示生物的宿主介导试验，对小鼠进行诱变性测试。两种试验均未检测到诱变效应。