槲皮素对中国仓鼠肺细胞培养物的致突变性。
Mutagenicity of quercetin in Chinese hamster lung cells in culture.
作者信息
Nakayasu M, Sakamoto H, Terada M, Nagao M, Sugimura T
出版信息
Mutat Res. 1986 May;174(1):79-83. doi: 10.1016/0165-7992(86)90081-3.
PMID:3702909
Abstract
Quercetin, a flavonol that is widely distributed in edible plants, was assayed for cytotoxic and mutagenic activities on Chinese hamster lung cells in culture, using diphtheria toxin resistance as a selective marker. Results showed that it was cytotoxic, and induced a dose-dependent increase in the number of diphtheria-toxin-resistant mutants in the absence of a metabolic activation system.
摘要
槲皮素是一种广泛分布于可食用植物中的黄酮醇，利用对白喉毒素的抗性作为选择标记，检测了它对培养的中国仓鼠肺细胞的细胞毒性和致突变活性。结果表明，在没有代谢活化系统的情况下，它具有细胞毒性，并导致对白喉毒素抗性突变体数量呈剂量依赖性增加。
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