Endler A T, Zielinski C, Schernthaner G, Ludwig H
Wien Klin Wochenschr. 1978 Oct 27;90(20):747-51.
An increased incidence of infections, especially during periods of poor metabolic control is well known in patients with insulin-dependent diabetes mellitus. Therefore, we studied polymorphonuclear chemotaxis and its dependence on the degree of diabetic control in 49 patients with insulin-dependent diabetes mellitus in 46 controls. A modification of the chemotaxis assay described by Frei et al. was used as test system. The mean chemotactic activity observed in the total group of insulin-dependent diabetics did not differ from the values obtained in the controls. However, in patients with poor diabetic control and glucosuria exceeding 60 g/24h, a significantly reduced chemotactic leucoyte migration was found. These data indicate that normalization of leucotaxis can be achieved in insulin-dependent diabetes by means of adequate diabetes control.
胰岛素依赖型糖尿病患者感染发生率增加，尤其是在代谢控制不佳期间，这是众所周知的。因此，我们研究了49例胰岛素依赖型糖尿病患者和46例对照者的多形核白细胞趋化性及其对糖尿病控制程度的依赖性。采用Frei等人描述的趋化性测定法的改良方法作为测试系统。在胰岛素依赖型糖尿病患者的总组中观察到的平均趋化活性与对照组获得的值没有差异。然而，在糖尿病控制不佳且糖尿超过60 g/24小时的患者中，发现趋化性白细胞迁移明显减少。这些数据表明，通过适当控制糖尿病，胰岛素依赖型糖尿病患者的白细胞趋化性可恢复正常。
