[Fibrin fibrinogen degradation products in the urine and blood in patients with diabetes mellitus and renal complications].

Making use of immunoelectrophoretic method for semiquantitative determination, the fibrin/fibrinogen degradation products (FDP) were determined in urine and blood serum of 63 patients with diabetes mellitus with various vascular-degenerative and inflammatory complications in the kidneys as well as of 23 clinically healthy subjects. FDP presence in urine was found mainly in patients with diabetic nephropathy (in 32.6%). FDP in blood serum was found with significantly increased values in diabetic nephropathies (mean 14.9 mg/ml) and particularly in their advanced forms (mean 16.4 mg/ml), whereas in diabetics with chronic pyelonephritis, their content was increased in single cases (mean 1.9 mg/ml). A moderately manifested correlation of FDP in urine and serum with blood urea, serum creatinine and creatinine clearance was established as well as partly with protein quantity in urine and diastolic arterial pressure. The determination of FDP in urine and blood serum could serve as an additional sign in the differentiation of diabetic nephropathy and chronic pyelonephritis in diabetic patients.