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工业卫生数据:合规性、剂量与临床相关性。

Industrial hygiene data: compliance, dosage and clinical relevance.

作者信息

Rappaport S M, Spear R C, Yager J W

出版信息

West J Med. 1982 Dec;137(6):572-6.

Abstract

Much of the data collected by industrial hygienists on levels of airborne contaminants in the workplace is of marginal relevance to the needs and interests of physicians practicing occupational medicine. Several factors influence data collection. Regulatory agencies require rigid interpretation of exposure levels, yet concentrations of contaminants in the air environment vary considerably. This discrepancy suggests a different approach to dealing with the regulatory problem, one which recognizes its inherent statistical nature. Increased attention also should be devoted to basing sampling intervals more directly on toxicological measurements. These changes would result in the collection of environmental data of greater relevance to physicians, toxicologists and epidemiologists because such information would allow more realistic estimates of the hazard of a cumulative exposure for a given work population.

摘要

工业卫生学家收集的关于工作场所空气中污染物水平的许多数据,与从事职业医学的医生的需求和兴趣相关性不大。有几个因素影响数据收集。监管机构要求对接触水平进行严格解读,但空气环境中污染物的浓度差异很大。这种差异表明需要采用一种不同的方法来处理监管问题,即认识到其固有的统计性质的方法。还应更加注重使采样间隔更直接地基于毒理学测量。这些变化将导致收集到与医生、毒理学家和流行病学家更相关的环境数据,因为这些信息将使人们能够更实际地估计特定工作人群累积接触的危害。

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本文引用的文献

1
Air sampling in the assessment of continuous exposures to acutely-toxic chemicals. Part I--Strategy.
Am Ind Hyg Assoc J. 1981 Nov;42(11):831-8. doi: 10.1080/15298668191420765.
2
A more rational basis for air sampling programs.空气采样计划更合理的依据。
Am Ind Hyg Assoc J. 1966 Jan-Feb;27(1):1-12. doi: 10.1080/00028896609342786.
4
A most rational basis for air sampling programmes.
Ann Occup Hyg. 1977 Jul;20(1):65-84. doi: 10.1093/annhyg/20.1.65.
5
Short-term tests for carcinogens and mutagens.
Mutat Res. 1979 Sep;65(3):133-226. doi: 10.1016/0165-1110(79)90014-9.

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