Influence of allyl isopropyl acetamide on d-aminolevulinic acid and aminoacetone synthesis during postnatal development in rats.

In contrast to other groups we found an allyl isopropyl acetamide (AIA)-mediated induction of aminoketones (AK) in newborn rats. To further clarify this phenomenon, the development of d-amino-levulinic acid synthesis (ALAS) and aminoacetone synthesis (AAS) and their inducibility by AIA were determined during the first days of life, daily until the 5th day of life, and then up to an age of 240 days. Both ALAS and AAS decrease during the first 24 h of life; the inducibility of both is detectable 6 h after birth, and develops during the first day of life to reach maximal inducibility. Minimum values are observed between day 30-45 of life; thereafter a tendency of increasing basic activity (AAS) and constant (ALAS) or decreasing (AAS) inducibility is detectable.