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乙酰甘油醚磷酸胆碱对人血小板的刺激作用。

Human platelet stimulation by acetyl glyceryl ether phosphorylcholine.

作者信息

McManus L M, Hanahan D J, Pinckard R N

出版信息

J Clin Invest. 1981 Mar;67(3):903-6. doi: 10.1172/jci110108.

DOI:10.1172/jci110108
PMID:7204562
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC370642/
Abstract

Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 microM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.

摘要

乙酰甘油醚磷酸胆碱（AGEPC）在枸橼酸化的富含人血小板血浆中诱导剂量依赖性的血小板聚集以及[3H]5-羟色胺和血小板因子4的释放。ADP清除剂或吲哚美辛可预防由0.2微摩尔AGEPC诱导的不可逆血小板聚集反应，但对血小板分泌无影响；前列环素可抑制AGEPC诱导的聚集和分泌。乙二胺四乙酸（EDTA）或乙二醇双四乙酸（EGTA）可抑制AGEPC诱导的聚集，但对血小板分泌无影响。

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Human platelet stimulation by acetyl glyceryl ether phosphorylcholine.乙酰甘油醚磷酸胆碱对人血小板的刺激作用。
J Clin Invest. 1981 Mar;67(3):903-6. doi: 10.1172/jci110108.
2
Effects of acetyl glyceryl ether phosphorylcholine on human platelet function in vitro.
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3
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4
Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor).1-O-十六烷基/十八烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（血小板活化因子）对兔血小板磷脂酶的激活作用及血栓素的合成
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Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence.乙酰甘油磷酰胆碱对前列腺素I2刺激的人血小板中3',5'-环磷酸腺苷水平的抑制作用。血栓素A2依赖性的证据。
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Intravascular pathobiology of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF). I. Intravenous infusion in guinea pigs.乙酰甘油醚磷酸胆碱（AGEPC，一种合成的血小板活化因子（PAF））的血管内病理生物学。I. 豚鼠静脉输注。
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本文引用的文献

1
Release, purification, and characterization of platelet-activating factor (PAF).血小板活化因子（PAF）的释放、纯化及特性鉴定
Biochimie. 1980;62(4):251-9. doi: 10.1016/s0300-9084(80)80399-3.
2
Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine.从兔嗜碱性粒细胞中分离出的血小板活化因子被鉴定为乙酰甘油醚磷酸胆碱。
J Biol Chem. 1980 Jun 25;255(12):5514-6.
3
Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF).对人血清中一种可使血小板活化因子（PAF）失活的酸不稳定因子（ALF）的初步研究。
Clin Immunol Immunopathol. 1980 Mar;15(3):318-330. doi: 10.1016/0090-1229(80)90044-6.
4
Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils.从人中性粒细胞和单核细胞以及兔中性粒细胞和嗜碱性粒细胞中获得的血小板活化因子的物理和化学性质。
Biochim Biophys Acta. 1980 Feb 21;628(1):69-75. doi: 10.1016/0304-4165(80)90352-9.
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Human neutrophil-derived platelet activating factor.人中性粒细胞源性血小板活化因子
J Immunol. 1980 Feb;124(2):676-84.
6
Release of vasoactive amines from rabbit platelets induced by sensitized mononuclear leukocytes and antigen.致敏单核白细胞和抗原诱导兔血小板释放血管活性胺。
J Exp Med. 1970 Feb;131(2):287-306. doi: 10.1084/jem.131.2.287.
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Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils.血小板活化因子，一种来自兔和人嗜碱性粒细胞的过敏反应及免疫复合物沉积的新介质。
Nature. 1974 Jun 7;249(457):581-2. doi: 10.1038/249581a0.
8
Activation of human platelets by platelet activating factor (PAF) derived from sensitized rabbit basophils.源自致敏兔嗜碱性粒细胞的血小板活化因子（PAF）对人血小板的激活作用。
Immunology. 1978 Dec;35(6):953-8.
9
Platelet activating factor (PAF) induced release of platelet factor 4 (PF4) in vitro and during IgE anaphylaxis in the rabbit.血小板活化因子（PAF）在体外以及兔IgE过敏反应期间可诱导血小板因子4（PF4）的释放。
J Immunol. 1979 Dec;123(6):2835-41.
10
Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).血小板活化因子。1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱作为活性成分的证据（一类新的脂质化学介质）。
J Biol Chem. 1979 Oct 10;254(19):9355-8.