乙酰甘油醚磷酸胆碱对人血小板的刺激作用。
Human platelet stimulation by acetyl glyceryl ether phosphorylcholine.
作者信息
McManus L M, Hanahan D J, Pinckard R N
出版信息
J Clin Invest. 1981 Mar;67(3):903-6. doi: 10.1172/jci110108.
Abstract
Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 microM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.
摘要
乙酰甘油醚磷酸胆碱（AGEPC）在枸橼酸化的富含人血小板血浆中诱导剂量依赖性的血小板聚集以及[3H]5-羟色胺和血小板因子4的释放。ADP清除剂或吲哚美辛可预防由0.2微摩尔AGEPC诱导的不可逆血小板聚集反应，但对血小板分泌无影响；前列环素可抑制AGEPC诱导的聚集和分泌。乙二胺四乙酸（EDTA）或乙二醇双四乙酸（EGTA）可抑制AGEPC诱导的聚集，但对血小板分泌无影响。
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