Frosch P J, Wissing C
Arch Dermatol Res. 1982;272(3-4):269-78. doi: 10.1007/BF00509056.
This investigation examines the relationship between the sun sensitivity of human skin and its response to chemical irritants. Forty-four Caucasoid subjects with normal back skin were studied. The minimal erythema dose (MED) was determined with the sunburning spectrum of a high-pressure mercury lamp. Cutaneous irritability was quantified using a series of seven irritants of different chemical structure, solubility, and concentrations. The response was either expressed as a threshold value of exposure time (ammonium hydroxide, sodium hydroxide) or was graded after a standard exposure in intensity of whealing (dimethyl sulphoxide) or erythema (sodium lauryl sulphate, quaternium 1, croton oil, kerosene). A significant correlation between the MED and the response to all seven primary irritants was found. The relationship was better for water-soluble irritants than for lipid-soluble ones. Despite marked individual variations the determination of the MED is suggested as a valuable tool in identifying hyperirritable skin. Skin typing based on complexion and sunburn history proved to be less reliable.
本研究探讨了人体皮肤对阳光的敏感性与其对化学刺激物反应之间的关系。对44名背部皮肤正常的白种人受试者进行了研究。使用高压汞灯的晒伤光谱测定最小红斑量（MED）。使用一系列七种具有不同化学结构、溶解度和浓度的刺激物对皮肤刺激性进行量化。反应要么表示为暴露时间的阈值（氢氧化铵、氢氧化钠），要么在标准暴露后根据风团强度（二甲基亚砜）或红斑强度（十二烷基硫酸钠、季铵盐1、巴豆油、煤油）进行分级。发现MED与对所有七种主要刺激物的反应之间存在显著相关性。水溶性刺激物的相关性比脂溶性刺激物更好。尽管存在明显的个体差异，但MED的测定被认为是识别高敏皮肤的一种有价值的工具。基于肤色和晒伤史的皮肤分型被证明不太可靠。
