Frosch P J, Duncan S, Kligman A M
Br J Dermatol. 1980 Sep;103(3):263-74. doi: 10.1111/j.1365-2133.1980.tb07243.x.
The wealing response of human skin to dimethyl sulphoxide (DMSO) has been quantified. Concentrations of 90%, 95% and 100% were applied for 5 min circular areas 8 min in diameter. Wealing was scored on a five-point scale after 10 min. Marked individual variations were found. Wealing was strongly influenced by body region and was dose-dependent. The intensity of the reaction paralleled that to other irritants and was dependent mainly on thickness and integrity of the horny layer. The DMSO test is a simple, quick way to assess the barrier function of the stratum corneum.
已对人体皮肤对二甲基亚砜（DMSO）的风团反应进行了量化。分别将浓度为90%、95%和100%的DMSO涂抹于直径8分钟的圆形区域，持续5分钟。10分钟后，根据五分制对风团进行评分。发现个体差异显著。风团反应受身体部位的影响很大，且呈剂量依赖性。该反应的强度与对其他刺激物的反应强度相似，主要取决于角质层的厚度和完整性。DMSO试验是评估角质层屏障功能的一种简单、快速的方法。
