Calixto J B, Aucélio J G, Valle J R
Arch Int Pharmacodyn Ther. 1982 Nov;260(1):63-9.
The influence of androgen treatment during the neonatal period on the contractions induced in dog uteri by acetylcholine, oxytocin, histamine and barium chloride was studied in vitro. An increase in the sensitivity of preparations was observed to acetylcholine and oxytocin, represented by leftward shifts in the ED50 values of these agonists. On the other hand the ED50 values for histamine and barium chloride remained unchanged. The relative responsiveness (p) remained unaltered for all the agonists studied. These effects differ from those observed in the uterus of neonatally androgenized female rats.
研究了新生期雄激素处理对狗子宫在体外由乙酰胆碱、催产素、组胺和氯化钡诱导的收缩的影响。观察到制剂对乙酰胆碱和催产素的敏感性增加，表现为这些激动剂的半数有效剂量（ED50）值向左移动。另一方面，组胺和氯化钡的ED50值保持不变。所研究的所有激动剂的相对反应性（p）保持不变。这些效应与在新生期雄激素化的雌性大鼠子宫中观察到的效应不同。
