Ito H, Kasama K, Naruse S, Shimura K
Cancer Lett. 1982 Nov-Dec;17(2):197-203. doi: 10.1016/0304-3835(82)90032-5.
Palmitoleic acid (PLOA) markedly prolonged the survival time of mice bearing Ehrlich ascites tumor at doses of 37.5-150 mg/kg/day X 10, but the antitumor activity of oleic acid (OA) was weaker than that of PLOA. The total lipid and phospholipid contents in the tumor cells treated with PLOA were significantly decreased. In addition, the fatty acid pattern of phosphatidyl choline, cholesterol esters and triglycerides from the PLOA-treated Ehrlich tumor cells differed markedly from that of the corresponding lipids from the control tumor cells.
棕榈油酸（PLOA）以37.5 - 150毫克/千克/天×10的剂量显著延长了荷艾氏腹水瘤小鼠的存活时间，但油酸（OA）的抗肿瘤活性比PLOA弱。用PLOA处理的肿瘤细胞中的总脂质和磷脂含量显著降低。此外，PLOA处理的艾氏肿瘤细胞中磷脂酰胆碱、胆固醇酯和甘油三酯的脂肪酸模式与对照肿瘤细胞相应脂质的脂肪酸模式明显不同。
