Masters B R, Subramanian V H, Chance B
Curr Eye Res. 1982;2(5):317-21. doi: 10.3109/02713688209000776.
The suitability of water proton spin-lattice relaxation time T1 as a measure of corneal dysfunction is investigated in this paper. Proton nuclear magnetic resonance measurements were performed on excised rabbit corneas using the saturation recovery method to determine the proton spin-lattice relaxation time T1. Both freshly excised and progressively swollen rabbit corneas were studied. The experimental results are consistent with a two compartment model of "bound" water and "free" water. This model results in a linear correlation between 1 / T1 (measured) and 1/corneal hydration. This correlation suggests that water proton T1 values can be used as an index of corneal dysfunction.
本文研究了水质子自旋 - 晶格弛豫时间T1作为角膜功能障碍指标的适用性。使用饱和恢复法对切除的兔角膜进行质子核磁共振测量，以确定质子自旋 - 晶格弛豫时间T1。研究了新鲜切除的和逐渐肿胀的兔角膜。实验结果与“结合”水和“自由”水的双室模型一致。该模型导致1/T1（测量值）与角膜水合作用之间呈线性相关。这种相关性表明水质子T1值可作为角膜功能障碍的指标。
