Kahn A J
Growth. 1982 Winter;46(4):322-30.
In prior studies with CF1 mice obtained from a commercial source, the development of aversion to ethanol was accelerated by providing 5% sucrose (w/v) as only liquid source during age 4 to 8 weeks, but not when pretreatment was begun at age 12 weeks. In repeat studies the effect was not found consistently. The data suggested that this was due to changes in timing of the sensitive period associated with differences in the rate of development of aversion to ethanol. To keep breeding and rearing conditions as constant as possible, a mating colony was started with mice obtained from the commercial source. Successive generations of this line were studied. A spontaneous drift in the rate of development of aversion to ethanol, with increasing rates in successive generations, was observed. The sensitive period for the effect of 5% sucrose on this parameter was at age 8 to 12 weeks in the earlier more slowly developing generations; and gradually shifted to 0 to 4 weeks in later generations with a more rapid development of aversion to ethanol.
在先前使用从商业渠道获得的CF1小鼠进行的研究中，通过在4至8周龄时仅提供5%蔗糖（w/v）作为唯一液体来源，对乙醇厌恶的发展加速了，但在12周龄开始预处理时则没有加速。在重复研究中，该效应并未始终如一地被发现。数据表明，这是由于敏感期时间的变化与对乙醇厌恶发展速度的差异有关。为了尽可能保持繁殖和饲养条件恒定，从商业渠道获得的小鼠开始建立一个交配群体。对该品系的连续几代进行了研究。观察到对乙醇厌恶发展速度的自发漂移，在连续几代中速度不断增加。在早期发展较慢的世代中，5%蔗糖对该参数产生影响的敏感期在8至12周龄；而在后期对乙醇厌恶发展较快的世代中，敏感期逐渐转移到0至4周龄。
