Kahn A J
Growth. 1981 Winter;45(4):286-90.
The rate of development of aversion to ethanol was measured by the proportion of mice highly aversive to a 3% solution at age 24 weeks. Groups of C3H mice were exposed to either 0.5% or 5.0% ethanol during gestation or age 1 to 2 weeks, and for 1 week or 3 weeks at age 15 weeks. Male subjects only were studied. At age 24 weeks the groups exposed to 0.5% ethanol during gestation or age 1 to 2 weeks had significantly lower proportions of highly aversives to 3% ethanol than controls (38% and 46% versus 83%). Groups so exposed to 5.0% ethanol at an early age were not affected, nor were any group exposed to 0.5% or 5.0% ethanol at age 15 weeks. Groups of CF1 males were provided with 5.0% sucrose (w/v) as their only liquid source for one week beginning at age 4 weeks or 12 weeks. At age 24 weeks the group pretreated at age 4 weeks had a significantly greater proportion of subjects highly aversive to 3% ethanol than controls (63% versus 13%). The group pretreated at age 12 weeks was not significantly different from controls. Thus the rate of development of aversion to ethanol can be significantly decreased by exposure to 0.5% ethanol during a sensitive period, or significantly increased by exposure to 5% sucrose during a sensitive period.
通过24周龄时对3%乙醇溶液高度厌恶的小鼠比例来测量对乙醇厌恶的发展速率。将C3H小鼠组在孕期或1至2周龄时暴露于0.5%或5.0%的乙醇中，并在15周龄时暴露1周或3周。仅研究雄性个体。在24周龄时，孕期或1至2周龄时暴露于0.5%乙醇的组中，对3%乙醇高度厌恶的比例显著低于对照组（分别为38%和46%，而对照组为83%）。早期暴露于5.0%乙醇的组未受影响，15周龄时暴露于0.5%或5.0%乙醇的任何组也未受影响。CF1雄性小鼠组从4周龄或12周龄开始，以5.0%蔗糖（w/v）作为唯一液体来源，持续一周。在24周龄时，4周龄时进行预处理的组中，对3%乙醇高度厌恶的个体比例显著高于对照组（63%对13%）。12周龄时进行预处理的组与对照组无显著差异。因此，在敏感期暴露于0.5%乙醇可显著降低对乙醇厌恶的发展速率，而在敏感期暴露于5%蔗糖则可显著提高该速率。
