Kaler S G, Bixler D, Yu P L
J Craniofac Genet Dev Biol. 1982;2(3):205-13.
Fifteen patients with Crouzon syndrome were evaluated for abnormalities of hand bone length via metacarpophalangeal pattern profile analysis. Data from this group were compared to that from a normal control sample. A discriminant function, utilizing Z scores based on the lengths of three hand bones, was derived and distinguished between the two samples at a rate of 88.3%. The discriminant variables selected in the function represented hand bones that are prominently involved in ACS type V and ACPS type II, syndromes that feature craniofacial abnormalities not unlike those in Crouzon syndrome. The possibility of a common developmental mechanism affecting the hand skeleton in all three of these different conditions is raised.
通过掌指骨模式轮廓分析，对15例克鲁宗综合征患者的手部骨骼长度异常进行了评估。将该组数据与正常对照样本的数据进行了比较。利用基于三根手部骨骼长度的Z分数得出了一个判别函数，该函数区分两个样本的准确率为88.3%。该函数中选择的判别变量所代表的手部骨骼在Ⅴ型尖头并指综合征和Ⅱ型尖头多指综合征中明显受累，这两种综合征的颅面异常特征与克鲁宗综合征的颅面异常特征相似。这就提出了在这三种不同病症中影响手部骨骼的共同发育机制存在的可能性。
