血清咖啡因水平对用茶碱治疗呼吸暂停的早产儿心电图的影响。
Effect of serum caffeine level on pneumocardiogram of premature infants treated for apnea with theophylline.
作者信息
Banagale R C
出版信息
Med Hypotheses. 1982 Dec;9(6):639-42. doi: 10.1016/0306-9877(82)90056-1.
PMID:7167074
Abstract
It is speculated that measurement of serum theophylline concentration alone, without concomitant caffeine level determination, may lead to a false negative (normal) pneumocardiogram due to possible existence of therapeutic caffeine level resulting from the methylation of theophylline. Treatment of neonatal apnea with theophylline as documented by a normal follow-up pneumocardiogram should be considered successful only when the levels of both theophylline and caffeine have been documented subtherapeutic at time of re-test.
摘要
据推测，仅测量血清茶碱浓度而不同时测定咖啡因水平，可能会因茶碱甲基化产生的治疗性咖啡因水平的存在而导致假阴性（正常）的肺心动图。只有当再次检测时茶碱和咖啡因水平均被证明低于治疗水平时，以茶碱治疗新生儿呼吸暂停并经正常的后续肺心动图记录才可被认为是成功的。
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