Michalk D, Manz F, Muller-Wiefel D E, Scharer K
Miner Electrolyte Metab. 1982 Nov;8(5):255-60.
Excretion, clearance and tubular reabsorption of inorganic sulfate (SO4) were measured in 38 children with various chronic kidney disorders over a wide range of glomerular filtration rates (GFR). The SO4 excretion remained constant up to advanced renal failure. Significant correlations were found between GFR and clearance or tubular reabsorption of SO4, respectively. It appears that in early renal insufficiency the reduction of tubular SO4 reabsorption is sufficient to prevent an increase in plasma SO4. At GFR values below 30 ml/min/1.73 m2 about half of the children studied exhibited a net tubular secretion of SO4 and all patients showed a rapid increase of plasma SO4 up to 10 times mean normal levels. It is suggested that the accumulation of SO4 in uremia is less compensated for than that of other ions.
在38名患有各种慢性肾脏疾病、肾小球滤过率（GFR）范围广泛的儿童中，对无机硫酸盐（SO4）的排泄、清除率和肾小管重吸收进行了测量。在晚期肾衰竭之前，SO4排泄保持恒定。分别发现GFR与SO4清除率或肾小管重吸收之间存在显著相关性。看来在早期肾功能不全时，肾小管SO4重吸收的减少足以防止血浆SO4升高。在GFR值低于30 ml/min/1.73 m2时，约一半的受试儿童表现出SO4的净肾小管分泌，并且所有患者的血浆SO4均迅速升高至正常平均水平的10倍。有人提出，与其他离子相比，尿毒症中SO4的蓄积得到的代偿较少。
